Standing Margin of Stability in PwMS

Suggested read: Standing Margin of Stability as a Measure of Balance for people with Multiple Sclerosis (MS) [1]

Standing Margin of Stability is correlated with impairment due to Multiple Sclerosis.
Standing Margin of Stability complements established clinical scales.
Range of the Global Margin of Stability has the strongest correlation with impairment.

Global Margin of stability

The Margin of Stability (MoS) is a measure of the amount the centre of mass (adjusted based on it’s velocity) must move before someone will fall if they take no corrective action [2].

The MoS is conventionally measured in the Anterior-Posterior and Medio-Lateral directions, in my paper I introduce a new measure, the Global MoS, the shortest center of mass shift in any direction that would result in an unstable state.

Figure by Olivia F. Simpson, included as Figure 2 in the paper on the Standing MoS [1]

Standing Margin of Stability

The Margin of stability was developed for exploring balance in walking, and it has remained used primarily in walking studies, but in this work I analyse the standing of people with MS using MoS, for what I believe to be the first time.

Standing Margin of Stability and Multiple Sclerosis

I have shown that the standing Margin of stability is correlated with established measures of impairment due to MS.
This work also shows that the Global Margin of stability is a useful change to traditional methods of calculating the MoS.
Across the anterior-posterior, medio-lateral and Global standing MoS the measures of spread (Range and standard deviation) were best correlated with the level of balance impairment.
I conclude that the Range of the Global Margin of Stability when standing has the strongest correlation with impairment due to MS.

[1] Simpson OF, Stanev D, Pitt-Francis J, Zanon M, Rinderknecht MD, Zavatsky AB. Standing margin of stability as a measure of balance for people with multiple sclerosis. Clinical Biomechanics. 2025 Nov 7:106696. (doi.org/10.1016/j.clinbiomech.2025.106696)
[2] Hof AL, Gazendam MG, Sinke WE. The condition for dynamic stability. Journal of biomechanics. 2005 Jan 1;38(1):1-8.

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